• Journal title: Scientific Journal of Biological Sciences
  • ISSN: 2322-1968 (online)
  • Publisher: Sjournals
  • Country of publisher: iran, islamic republic of
  • Platform/Host/Aggregator: Sjournals
  • Date added to EuroPub: 2017/Feb/20

Subject and more

  • LCC Subject Category: Biological Sciences, Biochemistry, Bioinformatics, Biotechnology, Genetics, Marine Biology, Microbiology, Plant Sciences, Ecology,
  • Publisher's keywords: Cymbopogon citrates, Cytoarchitecture, Leaf extract, Light microscopic, Oral consumption, Phosphate buffered saline
  • Language of fulltext: english
  • Full-text formats available: PDF


    D.A. Adekomi*| Department of Anatomy and Cell Biology, Faculty of Basic Medical Sciences, Obafemi Awolowo University, Ile-Ife, Osun State, Nigeria., A.O. Adekeye| Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., O.O. Ogedengbe| Department of Anatomy, College of Medicine and Health Sciences, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria., R.Y. Ibiyeye| Department of Anatomy, Faculty of Basic Medical Sciences, University of Ilorin, Ilorin, Kwara State, Nigeria.




This investigation was to evaluate the histopathological effects of oral consumption of the aqueous leaf extract of Cymbopogon citratus on the frontal cortex of Sprague Dawley (SD) rats. Ten male SD rats weighing between 150-230g were used. The rats were randomly assigned into two groups designated as groups A and B. Group A served as the control group while group B was the treatment. 300 mg/kg body weight of the aqueous leaf extract of C. citratus was administered once daily for 14 consecutive days (14d) orally through a sterilized orogastric tube, while the control rats received equal volume of phosphate buffered saline (PBS). The rats were sacrificed 24 hours after the last administration. The frontal cortices were excised, fixed in 10% formol calcium for 18 hours and were processed for routine light microscopic study using Hematoxylin and Eosin (H&E) method. The histological findings revealed that the extract treated sections showed cytoarchitectural distortions ranging from neuronal degeneration, distortion, vacuolations and evidence of necrotic bodies while the sections from the rats in group B conform to normal histological profile. These findings suggest a deleterious and toxic effects of aqueous leaf extract of C. citratus on the frontal cortex of SD rats.

About Europub

ASRPC International is an amalgamation of Open Access Publications and worldwide international science conferences, workshops, database, scientific network and events. Established in the year 2011 with the sole aim of making the information on Sciences and technology "Open Access" (, ASRPC International publishes scholarly journals in all aspects of Science, Engineering, Management and Technology journals. ASRPC International has been instrumental in taking the knowledge on Science & technology to the doorsteps of ordinary men and women. Research Scholars, Students, Libraries, Educational Institutions, Research centers and the industry are main stakeholders that benefited greatly from this knowledge dissemination.